Depo-Provera is a drug, manufactured by The Upjohn Co., whose active ingredient is medroxyprogesterone acetate (MPA). FDA first approved the drug in 1959 to treat amenorrhea,5 irregular uterine bleeding, and threatened and habitual abortion. Medroxyprogesterone (Provera) treats conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding. Includes medroxyprogesterone side effects, interactions and indications. Learn about medroxyprogesterone (Provera) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. PROVERA tablets are indicated for the treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as fibroids or uterine cancer. Provera is a form of progesterone (a hormone) that is used to treat conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding. Provera is also used to decrease the risk of endometrial hyperplasia (a condition that may lead to uterine cancer) while taking estrogens. PROVERA is a medicine that contains medroxyprogesterone acetate, a progestin hormone. What is PROVERA used for? Treat menstrual periods that have stopped or to treat abnormal uterine bleeding. Provera is a progestin hormone used to treat menstrual periods that have stopped, abnormal uterine bleeding and to reduce the chances of getting uterine cancer. Medroxyprogesterone is used to treat amenorrhea (unusual stopping of menstrual periods) and abnormal uterine bleeding. It is also used to prevent endometrial hyperplasia (thickening of the lining of the uterus or womb) in women who are taking conjugated estrogens. This medicine is a progestin hormone. Find patient medical information for Medroxyprogesterone (Provera, Depo-Provera, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user. PROVERA is used to treat menstrual periods that have stopped or to treat abnormal uterine bleeding. Talk with your doctor about whether PROVERA is right for you.